Southampton will face Ajax and Udinese as the club prepares for its return to the Barclays Premier League.
The npower Championship runners-up will welcome Dutch champions Ajax to St Mary's on July 28, before Serie A outfit Udinese head to the south coast on August 11.
Saints will also host Wolves on August 4 and will travel to Bristol City three days later.
The club's four friendlies on English soil will be preceded by a seven-day training camp in Evian-les-Bains.
Nigel Adkins' side will play two matches in France, with a clash against an as-yet confirmed opponent and Ligue 1 side Evian.
Southampton recently announced Arsenal and Rangers will take part in the Markus Liebherr Memorial Cup on July 14.