Jamal Campbell-Ryce, Adam Reed and Jamie Smith could all be in the Leyton Orient squad for the trip to Tranmere.
Boss Russell Slade has brought in three new faces this week following the disappointing 4-2 defeat at Wycombe.
Winger Campbell-Ryce has rejoined the O's on loan from Bristol City and young midfielder Reed has signed from Sunderland until the end of the season.
Slade has also snapped up free-agent midfielder Smith on a short-term deal after he was released by Brighton earlier this season.
Dean Leacock limped off at Wycombe and will be checked over along with fellow defender Ryan Dickson (thigh), while midfielder Solomon Taiwo is suspended and striker Jonathan Tehoue has moved to Swindon on loan.
Tranmere duo Enoch Showunmi and Zoumana Bakayogo could be in contention for starts.
Showunmi and Bakayogo recently returned to fitness following respective leg and shin problems and both men featured from the bench as Rovers claimed a last-gasp 1-1 draw with Notts County on Tuesday night.
Boss Ronnie Moore still has a trio of injury absentees to occupy him in the second match of his third spell in charge at Prenton Park.
Martin Devaney (hamstring) and Adam McGurk (broken cheekbone) are both set for up to a month on the sidelines.
Mark McChrystal will also be out for a lengthy period following hernia surgery, but fellow defender David Raven has resumed training following a similar operation.