Fulham recorded a 1-0 win at Anfield, the first in their history as Liverpool's FA Cup final warm-up felt decidedly flat.
The Cottagers' previous 30 visits had failed to produce a victory and Merseyside, in general, has been an unhappy hunting ground.
Saturday's woeful 4-0 defeat to Everton at Goodison Park extended Fulham's run in league matches to no wins in 48 trips to the city of Liverpool.
But all that changed courtesy of Martin Skrtel's fifth-minute own goal and a severely-weakened Reds line-up as manager Kenny Dalglish made nine changes to protect his major stars in the pursuit of a second domestic trophy of the season on Saturday.
Liverpool were without the likes of top scorer Luis Suarez, captain Steven Gerrard, Daniel Agger, Craig Bellamy and goalkeeper Jose Reina.
But the absent players only enhanced their reputations as their team suffered back-to-back home defeats - having lost to West Brom last time out - and a fourth loss at home.
They have now dropped an astonishing 30 points at Anfield in the current campaign, having won just five times in 18 matches.
Liverpool's defeat meant Everton could establish a five-point lead in seventh place but they were held to a draw 1-1 at Stoke.
Cameron Jerome netted two minutes after coming off the bench to secure a point for Stoke, after the Toffees had gone in front in the 44th minute thanks to an own goal from the hosts' former Liverpool striker Peter Crouch.
The striker's unfortunate last touch sent the ball over the line after Tony Hibbert has delivered a cross into the box.
Jerome levelled in the 69th minute, making a forward burst and holding off two defenders before firing past Tim Howard.
While seventh-placed Everton will be disappointed not to make off with all three points, they have extended their unbeaten run in the league to seven games and, perhaps even more satisfyingly, their lead in the table over Merseyside rivals Liverpool.
Stoke, meanwhile, are up a place to 13th, two points away from the top half in which they are aiming to finish for the first time since their promotion to the division in 2008.