Godolphin's Mandaean and Mighty Ambition have been ruled out of Saturday's QIPCO 2000 Guineas at Newmarket.
Mandaean won twice from as many starts as a juvenile, when trained by Andre Fabre, but will not be making his debut for Mahmood Al Zarooni this weekend.
The Betfred Dante Stakes at York on May 17 is his first target of the campaign.
Mighty Ambition was a beaten favourite in last month's Craven Stakes and will have his sights lowered, instead of lining up in the Guineas.
Godolphin racing manager Simon Crisford said: "Neither will run in the Guineas.
"Mandaean is going for the Dante - we just kept him in the Guineas to see what the race was like.
"I think we'll find Mighty Ambition a Listed race somewhere."