Red Cadeaux aims to end an excellent first half of the season on a high in a competitive renewal of the Princess Of Wales's Goldsmiths Stakes at Newmarket.
Ed Dunlop's consistent six-year-old was agonisingly beaten a nose by Dunaden in last year's Melbourne Cup and finished third behind the same horse in the Hong Kong Vase on his final start of 2011.
He has taken his game to another level so far this season, winning the Yorkshire Cup and placing behind top-class middle-distance performers St Nicholas Abbey and Sea Moon on his last couple of appearances.
He has his sights lowered slightly in Thursday's Group Two, for what is likely to be his final appearance before his preparations for a second Melbourne Cup tilt begin.
"There should be a decent pace with Harris Tweed in the field, as he tends to make the running," said Dunlop.
"We have a 3lb penalty to contend with for his Yorkshire Cup win, but he's in good form and the ground is suitable for him, so we'll give it a go.
"We've waved the white flag with Dunaden as he's beaten us three times now, but our form is rock solid and he has obviously improved enormously this year.
"This will probably be his last run for a while, before we start thinking about Australia again, but we'll see."
Harris Tweed was a little under three lengths behind Red Cadeaux when third in the Yorkshire Cup and his trainer, William Haggas, admits he could be tough to beat.
Haggas said: "Our horse is very well and I wouldn't mind seeing a bit more rain for him - the more rain the better.
"Red Cadeaux has the penalty this time, but he's a very good and consistent horse and he'll probably win.
"But if I was running away from a six-year-old gelding, I wouldn't be doing my job properly, so we'll see what happens."
Newmarket-based Italian Marco Botti has a strong hand, saddling both Jakkalberry and Joshua Tree.
The former ran an excellent race in the Dubai Sheema Classic and is expected to improve on his fifth placed finish in the Hardwicke Stakes, although Botti is hoping there is no more rain at Headquarters.
He said: "Jakkalberry has come out of Royal Ascot in good order. We are just monitoring how much rain there is at Newmarket because he is a fast-ground horse - he would be fine with a little bit of cut in the ground but he wouldn't want it too soft.
"I think that he has definitely come on for his run in the Hardwicke Stakes. We gave him a break after he came back from Dubai and that race will have brought him on.
"His run in the Dubai Sheema Classic, when he had ideal conditions, was probably his best run to date.
"We are aiming him at the Melbourne Cup this year and there are a couple of options before then. He could head to Chicago in August or for the Geoffrey Freer Stakes at Newbury.
"Joshua Tree ran a good race in Italy. Being by Montjeu, he gets away with a little bit of cut in the ground but he wouldn't want it too soft either. He is a solid old horse and he ran some nice races out in Dubai at the start of the year.
"We are keen to get a run into him because we want to keep him fit for the new race on the Arlington Million card over a mile, five and a half furlongs. He's a horse who takes a lot of work so we need to run him to keep him fit."
James Fanshawe's Dandino was a close second behind Sea Moon on his penultimate start at Goodwood, but was then a beaten odds-on favourite over this course and distance late last month.
Oscar Yeadon, assistant racing manager for owners Elite Racing Club, said: "He's fine and well and has run well on each of his three starts this season.
"He ran a very good race against Sea Moon and the form has been franked since, obviously.
"We felt there were a few mitigating circumstances at Newmarket last time as the pace of the race wasn't really run to suit and we're trying him back on a bit easier ground.
"We know he's a very good horse on his day so if things go to plan, he gets the rub of the green and he shows his best form, then we're hopeful he'll be competitive."
Godolphin are represented by Modun, while Sir Michael Stoute saddles Fiorente.
The Luca Cumani-trained Quest For Peace and Sea Of Heartbreak from Roger Charlton's stable complete the nine-runner field.