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Arian Foster ran for 110 yards and a touchdown as the Houston Texans secured a 27-7 success at Jacksonville.
Ben Tate added 74 yards and two scores as the Texans improved to 2-0 for the third consecutive season by winning their fourth in a row against the AFC South rival Jaguars, who started 0-2 for the third time in the last five years.
The Texans gained 242 yards in the first half while building a 17-0 lead. Foster ran for 69 yards and a score. Tate added 49 and a touchdown. Matt Schaub, using mostly short throws, picked apart Jacksonville's defense.
The Jaguars were even worse on offense, finishing with a franchise-low 117 yards with Blaine Gabbert completing just 4 of 11 passes for 13 yards in the first half, was sacked twice and had two balls batted down at the line of scrimmage - both by JJ Watt.
Jacksonville had 43 yards in the first half, the third-fewest in franchise history.
They showed some life to open the second half, turning good field position into a touchdown. Gabbert hooked up with Laurent Robinson for 32 yards, and then found Maurice Jones-Drew in the flat for a 5-yard score.
It was Jones-Drew's 75th career touchdown. He joined Randy Moss, Tony Gonzalez and Antonio Gates as the only active players with at least 75 TDs.
But the Texans answered, driving 80 yards in 17 plays. Tate's 2-yard plunge made it 24-7 in the third quarter.
The Jaguars played without cornerback Derek Cox and linebacker Daryl Smith, but more pressing injuries came on the other side of the ball. They were without left guard Eben Britton and right tackle Cam Bradfield.
With four offensive linemen already on injured reserve, Jacksonville turned to veteran Herb Taylor to start at left guard. Taylor practice just three times this week - none in full pads - and had not played in a game since 2008.