CJ Spiller scored twice and finished with 123 yards rushing as the Buffalo Bills picked up a 35-17 win over the Kansas City Chiefs.
The Bills' high-priced Mario Williams-led defense then did the rest as Kyle Williams had two of the team's five sacks, and they forced three turnovers.
That included linebacker Nick Barnett forcing Peyton Hillis' fumble at the goal line to snuff out a scoring drive late in the first half.
Mario Williams also recovered quarterback Matt Cassel's fumble, which led to Scott Chandler's 10-yard touchdown catch in a first half during which the Bills took control by building a 21-0 lead.
Fitzpatrick went 10 of 19 for 178 yards and two touchdowns, including a 49-yarder to Stevie Johnson. And Buffalo's special teams contributed: Leodis McKelvin returned a punt 88 yards to make it 35-3 with 3:46 left in the third quarter.
Cassel finished 23 of 42 for 301 yards with two touchdowns and an interception, with much of that production coming after the Bills had built a 35-3 lead. Dwayne Bowe scored both touchdowns on 33- and 2-yard catches in the final seven minutes.
Spiller was unstoppable in scoring on the Bills' second and third possessions.
He accounted for 48 of Buffalo's 84 yards in scoring on a 17-yard run 13 minutes in.
He then scored on a 3-yard run on the Bills next drive, which he helped set up with a solid 38-yard run, when he burst through the middle before being tackled at the Chiefs 12.
Spiller became the fourth Bills player to reach 100 yards in the first two games of a season, joining Fred Jackson, Thurman Thomas and OJ Simpson, who did that twice.
McKelvin's TD return was the second of his career, and the second-longest in team history, 3 yards short of the record set by Keith Moody in 1977.