Wigan will host St Helens in the Challenge Cup quarter-finals but may play the tie at a neutral venue.
The old rivals were paired together in Tuesday morning's draw but with the tie set to be televised on Saturday May 12, it means that, as things stand, there are football and rugby league matches scheduled for the DW Stadium on consecutive days with the town's football club playing their final game of the season on May 13.
Widnes' Stobart Stadium is being considered as a potential venue. It staged a Wigan Super League play-off in 2009 following a similar clash.
A decision will made made after talks between Warriors chairman Ian Lenagan and ground owner Dave Whelan.
St Helens have not failed to reach the semi-finals for 11 years but they will be severely tested by the holders, who won 28-10 at Langtree Park on Good Friday.
That was Saints' only defeat in seven matches since caretaker coaches Mike Rush and Keiron Cunningham took charge following the sacking of Royce Simmons.
Whatever the outcome of the venue talks, Wigan coach Shaun Wane says he is happy with the draw.
"I'm pleased with that,'' he said. "It's great for the town. If we are going to get to the final we're going to come up against great teams.''
Ex-Wigan player Wane described himself as the "happiest man in the north-west'' after his side gained a 28-10 win over Saints in the Good Friday derby but he is expecting a tougher test in the cup.
"This is a fresh start,'' he said. "Jonny Lomax didn't play much game time against us that day.
"We know they're a quality team. It's about us being intense and doing the same job on them.
"I enjoyed it a few weeks ago and hopefully I'll enjoy this one. I know my players will want to make it two out of two because they know what it means to me and all the staff and the fans.
"To get them to the DW in the Cup with a chance to progress to the semi-final is massive for us. I'm looking forward to a real tough game.''
Meanwhile, Championship minnows Leigh have been rewarded for their cup run with a home tie against Leeds, while Huddersfield will entertain the London Broncos and Warrington face a tricky tie away against Catalan Dragons.
Super League champions Leeds, who lost to Wigan in last season's final, will be wary of underestimating Leigh in their tie.
Table-topping Huddersfield will fancy their chances of advancing to the last four, especially given the Broncos' poor away form.
Nothing is so certain for Warrington, though, with the 2009 and 2010 champions having lost 44-16 away to the Dragons on Easter Monday.
Wolves coach Tony Smith sees the cup tie as a chance for his team to redeem themselves for their heavy defeat and believes they will be better prepared this time.
"Not using it as an excuse, but it was Easter and we had to go the day before and travel from Barcelona," he said.
"Given the choice we'll probably go a little earlier this time at a better time of day and hopefully not to Barcelona. It won't guarantee a performance but it will certainly help.
"It's a tough one but we'd like to think we can go and perform a bit better than we did last time. Unless you do, you can get embarrassed by the Catalans, as we found out."
The Wolves could still be without hooker Michael Monaghan and prop and captain Adrian Morley, who are still struggling to overcome knee and neck injuries respectively.
"It's frustrating for them but the team is doing okay without them so we're going with fit and healthy people at the moment," said Smith.
Full-back Brett Hodgson is expected to line up against Salford at the Halliwell Jones Stadium on Sunday despite taking a heavy tackle in last Saturday's Cup win over Bradford which resulted in a grade D charge being brought against forward John Bateman.
"He was a bit shaken up but he's a tough hombre," added Smith. "He got up and continued, which he wouldn't have done if he wasn't all right."
Huddersfield v London Broncos
Catalan Dragons v Warrington
Leigh v Leeds
Wigan v St Helens