Super League leaders Wigan will be without prop forwards Paul Prescott and Ben Flower for up to six weeks due to injury.
Prescott damaged knee ligaments in the Warriors' 18-4 Challenge Cup quarter-final win over St Helens on Saturday, while Flower injured a hamstring playing for the under-20s side at the weekend.
"Ben would have played this week so sadly those two are out for the forseeable future," said Wigan coach Shaun Wane.
"It does, however, give a chance to some of our youngsters, Gil Dudson and Dom Crosby and the like, who are ready to play and I have put pressure on our junior coaches to make sure these sort of players are up to speed and are ready to come into our team."
Wigan are monitoring another front-rower, Epalahame Lauaki, who was knocked out in the cup tie, but centre Darrell Goulding is set to return for Friday's clash with second-placed Huddersfield at the Galpharm Stadium.