Jo-Wilfried Tsonga will play Fernando Verdasco in the last 16 of the Monte Carlo Masters.
Tsonga safely negotiated a tricky opener against Phillipp Kohlschreiber on Tuesday to progress.
The French fourth seed, in action on his 27th birthday, celebrated the occasion with an impressive 6-2 6-4 victory.
For the second day running, Spaniard Verdasco rallied from a set down before prevailing 3-6 6-3 6-1 against Croatia's Ivan Dodig.
In the first round, seeds Feliciano Lopez and Florian Mayer both fell to defeat.
Spanish 10th seed Lopez was beaten 6-1 6-4 by Stanislas Wawrinka and 14th seed Mayer went down 3-6 6-1 6-3 to qualifier Mikhail Kukushkin.
Juan Monaco, seeded 11, also fell as he was forced to retire when 7-5 0-6 2-3 down against Robin Haase after rolling his ankle. However, 12th seed Kei Nishikori progressed with a 6-2 7-5 win over Spain's Albert Ramos.
Unseeded Croatian Marin Cilic enjoyed a 6-3 6-4 win over Italy's Simone Bolelli, while there were also wins for Andreas Seppi, who now plays top seed Novak Djokovic, Fabio Fognini, Potito Starace, Thomaz Bellucci, Pablo Andujar and Filippo Volandri.