British number one Elena Baltacha will play former finalist Sam Stosur in the first round of the French Open.
The duo were paired together when the draw was made in Paris on Friday.
Stosur, the world number six, reached the final at Roland Garros two years ago before losing to Francesca Schiavone.
Fellow Briton Anne Keothavong would appear to have a more winnable game against Melinda Czink.
Hungarian Czink is ranked 116th - 40 places below Keothavong.
Heather Watson, who qualified for the main draw earlier in the day, will face Russia's world number 80 Elena Vesnina. Watson is ranked 29 places lower but did not lose a set in qualifying.
Tournament favourite Serena Williams landed in the same quarter as Maria Sharapova.
Williams will open against France's Virginie Razzano, while Sharapova plays Alexandra Cadantu in round one.
The winner of that scheduled quarter-final will meet Wimbledon champion Petra Kvitova in the semi-finals if the seedings play out. Kvitova could first have to get past defending champion Li Na at the last-eight stage though.
Li opens her title defence against Sorana Cirstea, while Kvitova will meet Australian teenager Ashleigh Barty.
On the weaker-looking other side of the draw, top seed Victoria Azarenka will open against Alberta Brianti. She is seeded to face Stosur in the last eight and Agnieszka Radwanska in the semis.